Viagra pharmacokinetics

Categories: Viagra Canada

Viagra quickly mixes with the blood after oral use. It reaches the average bioavailability of 41% . The Viagra studies have shown that the pharmacokinetics of sildenafil change with the dose. On the average the peak plasma level of sildenafil is 2 hours post dose. After this max is reached the medication’s effect starts slowly decrease. So, men who take Viagra should use it 30-45 minutes before sex and remember that its action reduces after the 2 hours past post dose.

The absorption parameters of the drug are affected by the food intake. The use of food is not recommended with Viagra. The medication works better on an empty stomach.

Sildenafil undergoes hepatic metabolism and is eliminated in the feces (80%) and in the urine (13%).

The medication plasma concentrations may be changed if other medications are used concomitantly. The use of erythromycin, ketoconazole, itraconazole, and cimetidine may increase the level of sildenafil in plasma.

Sildenafil does not produce any changes in the quality and quantity of the semen.

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