Buy Viagra Canada mode of action

Categories: Viagra Canada

The mode of action of Viagra involves several complex processes. First of all, a man should be sexually stimulated for the medication can start its work. When a person is aroused, the nitric oxide is released in the corpus cavernosum of his penis. This substance plays a crucial role in the process of achieving erection. Nitric oxide activates the enzyme guanylate cyclase, this in turn increases the levels of cyclic guanosine monophosphate (cGMP). All these processes result in smooth muscle relaxation in the corpus cavernosum and blood inflow into the penis.

Sildenafil with the release of the nitric oxide starts to stop and prevent the increased levels of phosphodiesterase type 5 (PDE5). PDE5 enzyme is proven to reduce the levels of of cGMP in the corpus cavernosum. So Sildenafil contributes to increased levels of cGMP in the corpus cavernosum and to smooth muscle relaxation. Extra blood flows into the penile tissue and fills it. The penis gets hard and erect.

Sildenafil works selectively for PDE5 enzyme, still it may have mild effect on other PDEs.

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